Confirmatory Factor Analyses Using Neuropsychiatric Inventory Data
from the National Alzheimer's Coordinating Center 
 
   Lead Investigator:    David Johnson
   Institution      :    University of Kansas
   E-Mail           :    dkj@ku.edu
   Proposal ID      :    23


   Publications:


1  Johnson DK, Watts A, Chapin BA, Anderson R, Burns JM
   Neuropsychiatric Profiles in Dementia
   Journal Article  Alzheimer Dis Assoc Disord,25:326-332,2011,PMC3218373

   PUBLISHED





   Proposal Description:
   Hypothesis and Brief Rational  Using single and multigroup confirmatory factor analysis we can characterize neuropsychiatric  profile of normal subjects and explore the possibility that there are distinct NPI data profiles or patterns  for different types of dementia. We hypothesize that when compared to healthy older adult controls???  (1) Dementia of the Alzheimer Type (DAT) and Vascular Dementia (VD) will show a unique  depressive/passivity psychiatric symptom complex,  (2) Parkinson???s Disease with Dementia (PDD) and Dementia with Lewy Bodies (DLB) will show an  agitation/fluctuation symptom complex, and  (3) these two symptom complexes will reliably discriminate AD/VD from PDD/DLB.